Medium Optimization for Penicillin Acylase (PAc) Production by Recombinant B. megaterium MS941 Containing pac Gene from B. thuringiensis BGSC BD1 Using Response Surface Methodology

Medium Optimization for Penicillin Acylase (PAc) Production by Recombinant B. megaterium MS941 Containing pac Gene from B. thuringiensis BGSC BD1 Using Response Surface Methodology

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Penicillin G acylase (PAc) hydrolyses of the amide bond of benzylpenicillin (Pen-G) releasing PAA and 6-APA, key intermediate in the production of various semisynthetic penicillins. In this study, we optimised the production medium of PAc by RSM using two variables (xylose as inducer and CaCl2 as d...

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Bibliographic Details
Main Authors: FENTRI PARAMITHA PUTRI, ASTUTIATI NURHASANAH, NIKNIK NURHAYATI, IS HELIANTI, KHASWAR SYAMSU
Format: Article
Language:English
Published: Indonesian Society for Microbiology 2015-06-01
Series:Microbiology Indonesia
Subjects:
Bacillus megaterium btpacBD1
CCD
CaCl2
Penicillin acylase
xylose
Online Access:https://jurnal.permi.or.id/index.php/mionline/article/view/324

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https://jurnal.permi.or.id/index.php/mionline/article/view/324

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