Effective Glycosylation of Cucurbitacin Mediated by UDP-Glycosyltransferase UGT74AC1 and Molecular Dynamics Exploration of Its Substrate Binding Conformations

Effective Glycosylation of Cucurbitacin Mediated by UDP-Glycosyltransferase UGT74AC1 and Molecular Dynamics Exploration of Its Substrate Binding Conformations

Cucurbitacins, a group of diverse tetracyclic triterpenes, display a variety of biological effects. Glycosylation mediated by glycosyltransferases (UGTs) plays a vital role in structural and functional diversity of natural products and influences their biological activities. In this study, GT-SM, a...

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Bibliographic Details
Main Authors: Shicheng Mu, Jiao Li, Cui Liu, Yan Zeng, Yan Men, Yi Cai, Ning Chen, Hongwu Ma, Yuanxia Sun
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Catalysts
Subjects:
glycosyltransferase
glycosylation
natural products
cucurbitacins
UDP-glucose regeneration
Online Access:https://www.mdpi.com/2073-4344/10/12/1466

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https://www.mdpi.com/2073-4344/10/12/1466

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