Dendritic cell plasticity in tumor-conditioned skin: CD14+ cells at the cross-roads of immune activation and suppression

Dendritic cell plasticity in tumor-conditioned skin: CD14+ cells at the cross-roads of immune activation and suppression

Tumors abuse myeloid plasticity to re-direct dendritic cell (DC) differentiation from T cell stimulatory subsets to immune suppressive subsets that can interfere with antitumor immunity. Lined by a dense network of easily accessible DC the skin is a preferred site for the delivery of DC-targeted vac...

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Bibliographic Details
Main Authors: Rieneke evan de Ven, Jelle Jan Lindenberg, Dinja eOosterhoff, Tanja Denise De Gruijl
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Immunology
Subjects:
Dendritic Cells
Macrophages
Skin
Cancer
immune suppression
human DC subsets
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00403/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00403/full

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