Modeling protein-protein interactions in axon initial segment to understand their potential impact on action potential initiation

Modeling protein-protein interactions in axon initial segment to understand their potential impact on action potential initiation

The axon initial segment (AIS) region is crucial for action potential initiation due to the presence of high-density AIS protein voltage-gated sodium channels (Nav). Nav channels comprise several serine residues responsible for the recruitment of Nav channels into the structure of AIS through intera...

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Bibliographic Details
Main Authors: Piyush Bhardwaj, Don Kulasiri, Sandhya Samarasinghe
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Neural Regeneration Research
Subjects:
alzheimer’s disease; ankyrin-g; axon initial segment; casein kinase-2; microtubules; voltage-gated potassium channel; voltage-gated sodium channel
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=4;spage=700;epage=706;aulast=Bhardwaj

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=4;spage=700;epage=706;aulast=Bhardwaj

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