Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases

Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases

Mutations in LRRK2 are the most common genetic cause of Parkinson's disease (PD). The most prevalent LRRK2 mutation is the G2019S coding change, located in the kinase domain of this complex multi-domain protein. The majority of G2019S autopsy cases feature typical Lewy Body pathology with a cli...

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Bibliographic Details
Main Authors: Adamantios Mamais, Meera Raja, Claudia Manzoni, Sybille Dihanich, Andrew Lees, Darren Moore, Patrick A. Lewis, Rina Bandopadhyay
Format: Article
Language:English
Published: Elsevier 2013-10-01
Series:Neurobiology of Disease
Subjects:
LRRK2
G2019S
α-Synuclein
Differential solubility
Immunohistochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113001599

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http://www.sciencedirect.com/science/article/pii/S0969996113001599

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