Proline to Threonine Mutation at Position 162 of NS5B of Classical Swine Fever Virus Vaccine C Strain Promoted Genome Replication and Infectious Virus Production by Facilitating Initiation of RNA Synthesis

Proline to Threonine Mutation at Position 162 of NS5B of Classical Swine Fever Virus Vaccine C Strain Promoted Genome Replication and Infectious Virus Production by Facilitating Initiation of RNA Synthesis

The 3′untranslated region (3′UTR) and NS5B of classical swine fever virus (CSFV) play vital roles in viral genome replication. In this study, two chimeric viruses, vC/SM3′UTR and vC/b3′UTR, with 3′UTR substitution of CSFV Shimen strain or bovine viral diarrhea virus (BVDV) NADL strain, were construc...

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Bibliographic Details
Main Authors: Huining Pang, Ling Li, Hongru Liu, Zishu Pan
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Viruses
Subjects:
classical swine fever virus
3′untranslated region
NS5B
RNA-dependent RNA polymerase
replication
initiation
Online Access:https://www.mdpi.com/1999-4915/13/8/1523

Internet

https://www.mdpi.com/1999-4915/13/8/1523

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