Chemically Modified SDF-1α mRNA Promotes Random Flap Survival by Activating the SDF-1α/CXCR4 Axis in Rats

Chemically Modified SDF-1α mRNA Promotes Random Flap Survival by Activating the SDF-1α/CXCR4 Axis in Rats

Random skin flaps are frequently applied in plastic and reconstructive surgery for patients suffering from soft tissue defects caused by congenital deformities, trauma and tumor resection. However, ischemia and necrosis in distal parts of random skin flaps remains a common challenge that limits the...

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Bibliographic Details
Main Authors: Zucheng Luo, Yujie Bian, Gang Zheng, Huijing Wang, Bingqian Yan, Wenting Su, Wei Dong, Zhichao Hu, Jian Ding, Anyuan Wang, Shi Li, Wei Fu, Jixin Xue
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
SDF-1α
modRNA
SDF-1α/CXCR4
regeneration
random skin flap
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.623959/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.623959/full

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