Isolation and characterization of antibody fragments selective for human FTD brain derived TDP-43 variants

Isolation and characterization of antibody fragments selective for human FTD brain derived TDP-43 variants

Abstract Background Frontotemporal dementia (FTD) is the second leading cause of early onset dementia following Alzheimer’s disease. It involves atrophy of the frontal and temporal regions of the brain affecting language, memory, and behavior. Transactive response DNA-binding protein 43 (TDP-43) pat...

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Bibliographic Details
Main Authors: Lalitha Venkataraman, Ping He, Galam Khan, Brent T. Harris, Michael R. Sierks
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Neuroscience
Subjects:
Frontotemporal dementia
TDP-43 variants
scFv
Biomarker
Brain tissue
Sera
Online Access:http://link.springer.com/article/10.1186/s12868-020-00586-0

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http://link.springer.com/article/10.1186/s12868-020-00586-0

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