E4F1 Is a Master Regulator of CHK1-Mediated Functions

E4F1 Is a Master Regulator of CHK1-Mediated Functions

It has been previously shown that the polycomb protein BMI1 and E4F1 interact physically and genetically in the hematopoietic system. Here, we report that E4f1 is essential for hematopoietic cell function and survival. E4f1 deletion induces acute bone marrow failure characterized by apoptosis of pro...

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Bibliographic Details
Main Authors: David Grote, Céline Moison, Stéphanie Duhamel, Jalila Chagraoui, Simon Girard, Jay Yang, Nadine Mayotte, Yan Coulombe, Jean-Yves Masson, Grant W. Brown, Sylvain Meloche, Guy Sauvageau
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715002727

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http://www.sciencedirect.com/science/article/pii/S2211124715002727

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