An Excitatory and Epileptogenic Effect of Dentate Gyrus Mossy Cells in a Mouse Model of Epilepsy

Summary: The sparse activity of hippocampal dentate gyrus (DG) granule cells (GCs) is thought to be critical for cognition and behavior, whereas excessive DG activity may contribute to disorders such as temporal lobe epilepsy (TLE). Glutamatergic mossy cells (MCs) of the DG are potentially critical...

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Bibliographic Details
Main Authors: Justin J. Botterill, Yi-Ling Lu, John J. LaFrancois, Hannah L. Bernstein, David Alcantara-Gonzalez, Swati Jain, Paige Leary, Helen E. Scharfman
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719314330