Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease

Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease

The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the MPTP-based model of Parkinson’s disease. Brain inflammation, microglia and astroglia...

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Bibliographic Details
Main Authors: Irene García-Domínguez, Karolina Veselá, Juan García-Revilla, Alejandro Carrillo-Jiménez, María Angustias Roca-Ceballos, Marti Santiago, Rocío M. de Pablos, José L. Venero
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Parkinson’s disease
peripheral inflammation
microglia
lipopolysaccharide
neuroinflammation
MPTP
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00398/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00398/full

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