Stereoselective inhibition of the hERG1 potassium channel

Stereoselective inhibition of the hERG1 potassium channel

A growing number of drugs have been shown to prolong cardiac repolarization, predisposing individuals to life-threatening ventricular arrhythmias known as Torsades de Pointes. Most of these drugs are known to interfere with the human ether à-gogo related gene 1 (hERG1) channel, whose curren...

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Bibliographic Details
Main Authors: Liliana eSintra Grilo, Pierre-Alain eCarrupt, Hugues eAbriel
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-11-01
Series:Frontiers in Pharmacology
Subjects:
Long QT Syndrome
enantiomer
cardiotoxicity
cardiac channelopathies
hERG1
voltage-gated potassium channel
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2010.00137/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2010.00137/full

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