Non-proteolytic effect of β-site APP-cleaving enzyme 1 (BACE1) on sodium channel function

Non-proteolytic effect of β-site APP-cleaving enzyme 1 (BACE1) on sodium channel function

The β-site APP-cleaving enzyme 1 (BACE1) is widely known for its pivotal role in the amyloidogenic pathway leading to Alzheimer's disease. Here, we elaborate on the recent finding that auxiliary subunits of voltage-gated sodium channels (β2 and β4) are BACE substrates. BACE1 produced complex ef...

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Bibliographic Details
Main Authors: Tobias Huth, Karoline Schmidt-Neuenfeldt, Andrea Rittger, Paul Saftig, Karina Reiss, Christian Alzheimer
Format: Article
Language:English
Published: Elsevier 2009-02-01
Series:Neurobiology of Disease
Subjects:
BACE1
Alzheimer's disease
Neuronal excitability
Sodium channels
Nav1.2 α subunit
β2 and β4-subunits
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108002647

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http://www.sciencedirect.com/science/article/pii/S0969996108002647

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