Mechanism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke.

Mechanism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke.

Inhibition of soluble epoxide hydrolase (sEH) is a potential target of therapy for ischemic injury. sEH metabolizes neuroprotective epoxyeicosatrienoic acids (EETs). We recently demonstrated that sEH inhibition reduces infarct size after middle cerebral artery occlusion (MCAO) in type 1 diabetic mic...

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Bibliographic Details
Main Authors: Kristen L Zuloaga, Stephanie M Krasnow, Xinxia Zhu, Wenri Zhang, Sari A Jouihan, Robert E Shangraw, Nabil J Alkayed, Daniel L Marks
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4019567?pdf=render

Internet

http://europepmc.org/articles/PMC4019567?pdf=render

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