Internal Ribosome Entry Site Dramatically Reduces Transgene Expression in Hematopoietic Cells in a Position-Dependent Manner

Internal Ribosome Entry Site Dramatically Reduces Transgene Expression in Hematopoietic Cells in a Position-Dependent Manner

Bicistronic transgene expression mediated by internal ribosome entry site (IRES) elements has been widely used. It co-expresses heterologous transgene products from a message RNA driven by a single promoter. Hematologic gene delivery is a promising treatment for both inherited and acquired diseases....

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Bibliographic Details
Main Authors: Qingyun Zheng, Xueyan Zhang, Hua Yang, Jinyan Xie, Yilin Xie, Jinzhong Chen, Chenghui Yu, Chen Zhong
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Viruses
Subjects:
internal ribosome entry site (ires)
recombinant adeno-associated virus vector
hematopoietic cells
bicistronic transgene
gene therapy
Online Access:https://www.mdpi.com/1999-4915/11/10/920

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https://www.mdpi.com/1999-4915/11/10/920

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