Defining Bedaquiline Susceptibility, Resistance, Cross-Resistance and Associated Genetic Determinants: A Retrospective Cohort Study

Defining Bedaquiline Susceptibility, Resistance, Cross-Resistance and Associated Genetic Determinants: A Retrospective Cohort Study

Background: Bedaquiline (BDQ) is a novel agent approved for use in combination treatment of multi-drug resistant tuberculosis (MDR-TB). We sought to determine BDQ epidemiological cut-off values (ECVs), define and assess interpretive criteria against putative resistance associated variants (RAVs), mi...

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Bibliographic Details
Main Authors: Nazir A. Ismail, Shaheed V. Omar, Lavania Joseph, Netricia Govender, Linsay Blows, Farzana Ismail, Hendrik Koornhof, Andries W. Dreyer, Koné Kaniga, Norbert Ndjeka
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:EBioMedicine
Subjects:
Tuberculosis
Bedaquiline
Clofazimine
Mic
Mutation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396418300057

Internet

http://www.sciencedirect.com/science/article/pii/S2352396418300057

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