Cumulative mitochondrial activity correlates with ototoxin susceptibility in zebrafish mechanosensory hair cells

Mitochondria play a prominent role in mechanosensory hair cell damage and death. Although hair cells are thought to be energetically demanding cells, how mitochondria respond to these demands and how this might relate to cell death is largely unexplored. Using genetically encoded indicators, we foun...

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Bibliographic Details
Main Authors: Sarah B Pickett, Eric D Thomas, Joy Y Sebe, Tor Linbo, Robert Esterberg, Dale W Hailey, David W Raible
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/38062