Is the survival of patients treated with ipilimumab affected by antibiotics? An analysis of 1585 patients from the French National hospital discharge summary database (PMSI)

Is the survival of patients treated with ipilimumab affected by antibiotics? An analysis of 1585 patients from the French National hospital discharge summary database (PMSI)

Background: The gut microbiota has a key role in the regulation of the immune system. Disruption of the gut microbiota’s composition by antibiotics might significantly affect the efficacy of immune checkpoint inhibitors. In a study of patients treated with ipilimumab, we sought to assess the relatio...

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Bibliographic Details
Main Authors: Pierre-Yves Cren, Nicolas Bertrand, Marie-Cécile Le Deley, Michaël Génin, Laurent Mortier, Pascal Odou, Nicolas Penel, Emmanuel Chazard
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
melanoma
ipilimumab
immune checkpoint inhibitor
immunotherapy
infection
antibiotics
gut microbiota
data reuse
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1846914

Internet

http://dx.doi.org/10.1080/2162402X.2020.1846914

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