NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities

NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities

Immune-mediated arthritis is an important chronic inflammatory disease of joints causing debilitating morbidity in affected patients. The mechanisms underlying immune-mediated arthritis have been intensively investigated, however the cellular and molecular factors contributing to the joint inflammat...

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Bibliographic Details
Main Authors: Yi-Chu Liao, Szu-Yu Wu, Ya-Fang Huang, Pei-Chi Lo, Tzu-Yi Chan, Chih-An Chen, Chun-Hsin Wu, Che-Chia Hsu, Chia-Liang Yen, Peng-Chieh Chen, Chi-Chang Shieh
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
NOX2
chronic granulomatous disease
serum-induced arthritis
neutrophils
immune checkpoint
reactive oxygen species
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.743030/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.743030/full

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