Evidence for the Inhibition by Temozolomide, an Imidazotetrazine Family Alkylator, of Intermediate-Conductance Ca2+-Activated K+ Channels in Glioma Cells

Evidence for the Inhibition by Temozolomide, an Imidazotetrazine Family Alkylator, of Intermediate-Conductance Ca2+-Activated K+ Channels in Glioma Cells

Background: Temozolomide (TMZ), an oral alkylator of the imidazotetrazine family, is used to treat glioma. Whether this drug has any ionic effects in glioma cells remains largely unclear. Methods: With the aid of patch-clamp technology, we investigated the effects of TMZ on the ionic currents in U37...

Full description

Bibliographic Details
Main Authors: Poh-Shiow Yeh, Shyh-Jong Wu, Te-Yu Hung, Yan-Ming Huang, Chia-Wei Hsu, Chun-I Sze, Yi-Jung Hsieh, Chin-Wei Huang, Sheng-Nan Wu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Temozolomide
Intermediate-conductance Ca2+-activated K+ channel
K+ current
Glioma cell
Membrane potential
Online Access:http://www.karger.com/Article/FullText/443112

Internet

http://www.karger.com/Article/FullText/443112

Similar Items