In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren

In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren

Abstract Ataluren promotes ribosomal readthrough of premature termination codons in mRNA which result from nonsense mutations. In vitro studies were performed to characterize the metabolism and enzyme kinetics of ataluren and its interaction potential with CYP enzymes. Incubation of [14C]‐ataluren w...

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Bibliographic Details
Main Authors: Ronald Kong, Jiyuan Ma, Seongwoo Hwang, Young‐Choon Moon, Ellen M. Welch, Marla Weetall, Joseph M. Colacino, Neil Almstead, John Babiak, Elizabeth Goodwin
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Pharmacology Research & Perspectives
Subjects:
CYP Inhibition and CYP Induction
Enzyme Kinetics
In vitro Metabolism
Reaction Phenotyping
UGT
Online Access:https://doi.org/10.1002/prp2.576

Internet

https://doi.org/10.1002/prp2.576

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