Dihydroquercetin Activates AMPK/Nrf2/HO-1 Signaling in Macrophages and Attenuates Inflammation in LPS-Induced Endotoxemic Mice

Dihydroquercetin Activates AMPK/Nrf2/HO-1 Signaling in Macrophages and Attenuates Inflammation in LPS-Induced Endotoxemic Mice

Dihydroquercetin (DHQ) is a flavonoid compound known for its anti-oxidant effects. Oxidative stress plays a dominant role in regulating the pathways associated with systemic inflammatory immune activation during endotoxemia. Whether and how DHQ regulates inflammatory responses in endotoxemia remains...

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Bibliographic Details
Main Authors: Liming Lei, Yunfei Chai, Haoming Lin, Chunbo Chen, Mingyi Zhao, Weiping Xiong, Jian Zhuang, Xiaoping Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
dihydroquercetin
endotoxemia
AMP-activated protein kinase
nuclear factor erythroid 2-related factor 2
heme oxygenase-1
anti-inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00662/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00662/full

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