Comparative gene identification 58/α/β hydrolase domain 5 lacks lysophosphatidic acid acyltransferase activity

Comparative gene identification 58/α/β hydrolase domain 5 lacks lysophosphatidic acid acyltransferase activity

Mutations in the gene encoding comparative gene identification 58 (CGI-58)/α/β hydrolase domain 5 (ABHD5) cause Chanarin-Dorfman syndrome, characterized by excessive triacylglycerol storage in cells and tissues. CGI-58 has been identified as a coactivator of adipose TG lipase (ATGL) and a lysophosph...

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Bibliographic Details
Main Authors: Derek McMahon, Anna Dinh, Daniel Kurz, Dharika Shah, Gil-Soo Han, George M. Carman, Dawn L. Brasaemle
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Journal of Lipid Research
Subjects:
phosphatidylinositol 3-phosphate
phosphatidylinositol 5-phosphate
adipose triglyceride lipase
Chanarin-Dorfman syndrome
neutral lipid storage disorder
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520353384

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http://www.sciencedirect.com/science/article/pii/S0022227520353384

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