Human Cytotoxic T Lymphocytes Form Dysfunctional Immune Synapses with B Cells Characterized by Non-Polarized Lytic Granule Release

Human Cytotoxic T Lymphocytes Form Dysfunctional Immune Synapses with B Cells Characterized by Non-Polarized Lytic Granule Release

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Suppression of the cytotoxic T cell (CTL) immune response has been proposed as one mechanism for immune evasion in cancer. In this study, we have explored the underlying basis for CTL suppression in the context of B cell malignancies. We document that human B cells have an intrinsic ability to resis...

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Bibliographic Details
Main Authors: Anna Kabanova, Francesca Sanseviero, Candi Veronica, Alessandra Gamberucci, Alessandro Gozzetti, Giuseppe Campoccia, Monica Bocchia, Cosima Tatiana Baldari
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716302194

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http://www.sciencedirect.com/science/article/pii/S2211124716302194

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