The human coronavirus HCoV-229E S-protein structure and receptor binding

The human coronavirus HCoV-229E S-protein structure and receptor binding

The coronavirus S-protein mediates receptor binding and fusion of the viral and host cell membranes. In HCoV-229E, its receptor binding domain (RBD) shows extensive sequence variation but how S-protein function is maintained is not understood. Reported are the X-ray crystal structures of Class III-V...

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Bibliographic Details
Main Authors: Zhijie Li, Aidan CA Tomlinson, Alan HM Wong, Dongxia Zhou, Marc Desforges, Pierre J Talbot, Samir Benlekbir, John L Rubinstein, James M Rini
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
coronavirus
HCoV-229E
spike protein
x-ray crystallography
electron cryomicroscopy
Online Access:https://elifesciences.org/articles/51230

Internet

https://elifesciences.org/articles/51230

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