Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers.

Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers.

Molecular subtypes of serous ovarian cancer have been recently described. Using data from independent datasets including over 900 primary tumour samples, we show that deregulation of the Let-7 pathway is specifically associated with the C5 molecular subtype of serous ovarian cancer. DNA copy number...

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Bibliographic Details
Main Authors: Åslaug Helland, Michael S Anglesio, Joshy George, Prue A Cowin, Cameron N Johnstone, Colin M House, Karen E Sheppard, Dariush Etemadmoghadam, Nataliya Melnyk, Anil K Rustgi, Wayne A Phillips, Hilde Johnsen, Ruth Holm, Gunnar B Kristensen, Michael J Birrer, Australian Ovarian Cancer Study Group, Richard B Pearson, Anne-Lise Børresen-Dale, David G Huntsman, Anna deFazio, Chad J Creighton, Gordon K Smyth, David D L Bowtell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3076323?pdf=render

Internet

http://europepmc.org/articles/PMC3076323?pdf=render

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