Immune Responses Following BCG Immunization of Infants in Uganda and United Kingdom Are Similar for Purified Protein Derivative but Differ for Secretory Proteins of Mycobacterium tuberculosis

Immune Responses Following BCG Immunization of Infants in Uganda and United Kingdom Are Similar for Purified Protein Derivative but Differ for Secretory Proteins of Mycobacterium tuberculosis

Introduction: The immunogenicity of BCG vaccination in infants differs between populations. We hypothesized that prenatal exposure to mycobacterial antigens might explain the differences in immune responses to BCG seen in other studies of infants in Africa and the United Kingdom (UK) and we explored...

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Bibliographic Details
Main Authors: Patrice A. Mawa, Mateusz Hasso-Agopsowicz, Lawrence Lubyayi, Grace Nabakooza, Marjorie Nakibuule, Rose Blitz, Li Dun, Abha Govind, Pontiano Kaleebu, Emily L. Webb, Alison M. Elliott, Hazel M. Dockrell, Stephen Cose, Steven G. Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
BCG vaccine
cytokine responses
chemokine responses
mycobacterial antigens
latent Mycobacterium tuberculosis infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.637114/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.637114/full

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