Combined Oral Administration of GABA and DPP-4 Inhibitor Prevents Beta Cell Damage and Promotes Beta Cell Regeneration in Mice

Combined Oral Administration of GABA and DPP-4 Inhibitor Prevents Beta Cell Damage and Promotes Beta Cell Regeneration in Mice

γ-aminobutyric acid (GABA) or glucagon-like peptide-1 based drugs, such as sitagliptin (a dipeptidyl peptidase-4 inhibitor), were shown to induce beta cell regenerative effects in various diabetic mouse models. We propose that their combined administration can bring forth an additive therapeutic eff...

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Bibliographic Details
Main Authors: Wenjuan Liu, Dong Ok Son, Harry K. Lau, Yinghui Zhou, Gerald J. Prud’homme, Tianru Jin, Qinghua Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Pharmacology
Subjects:
GABA
sitagliptin
streptozotocin
beta cell
diabetes
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00362/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00362/full

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