Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis

Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis

Chemokine synergy-inducing molecules are emerging as regulating factors in cell migration. The alarmin HMGB1, in its reduced form, can complex with CXCL12 enhancing its activity on monocytes via the chemokine receptor CXCR4, while the form containing a disulfide bond, by binding to TLR2 or TLR4, ini...

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Bibliographic Details
Main Authors: Valentina Cecchinato, Gianluca D'Agostino, Lorenzo Raeli, Alessandra Nerviani, Milena Schiraldi, Gabriela Danelon, Antonio Manzo, Marcus Thelen, Adrian Ciurea, Marco E. Bianchi, Anna Rubartelli, Costantino Pitzalis, Mariagrazia Uguccioni
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
cell migration
monocytes
CXCL12
HMGB1
thioredoxin
rheumatoid arthritis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02118/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02118/full

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