Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression

Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression

Expression of the checkpoint molecule programmed cell death protein 1 (PD-1) is considered a marker of T cells exhaustion. Here the authors show that CD8T cells isolated from breast cancer patients are perfectly functional despite PD-1 expression while those isolated from melanoma patients are not.

Bibliographic Details
Main Authors: Colt A. Egelston, Christian Avalos, Travis Y. Tu, Diana L. Simons, Grecia Jimenez, Jae Y. Jung, Laleh Melstrom, Kim Margolin, John H. Yim, Laura Kruper, Joanne Mortimer, Peter P. Lee
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06653-9

Internet

https://doi.org/10.1038/s41467-018-06653-9

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