ROCK (RhoA/Rho Kinase) in Cardiovascular–Renal Pathophysiology: A Review of New Advancements

Rho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors of the RhoA small GTPase and found to belong to the AGC family of serine/threonine kinases. They were shown to be downstream effectors of RhoA and RhoC activation. They signal via phosphorylation of protein...

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Bibliographic Details
Main Authors: Teresa M. Seccia, Matteo Rigato, Verdiana Ravarotto, Lorenzo A. Calò
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Journal of Clinical Medicine
Subjects:
Rho
Online Access:https://www.mdpi.com/2077-0383/9/5/1328