ROCK (RhoA/Rho Kinase) in Cardiovascular–Renal Pathophysiology: A Review of New Advancements
Rho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors of the RhoA small GTPase and found to belong to the AGC family of serine/threonine kinases. They were shown to be downstream effectors of RhoA and RhoC activation. They signal via phosphorylation of protein...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-05-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/9/5/1328 |
id |
doaj-ef0b0cbb7d3340e995504ff3c7f1ee32 |
---|---|
record_format |
Article |
spelling |
doaj-ef0b0cbb7d3340e995504ff3c7f1ee322020-11-25T02:39:14ZengMDPI AGJournal of Clinical Medicine2077-03832020-05-0191328132810.3390/jcm9051328ROCK (RhoA/Rho Kinase) in Cardiovascular–Renal Pathophysiology: A Review of New AdvancementsTeresa M. Seccia0Matteo Rigato1Verdiana Ravarotto2Lorenzo A. Calò3Department of Medicine, Hypertension Clinic, University of Padova, 35128 Padova, ItalyDepartment of Medicine, Nephrology, Dialysis and Transplantation Unit, University of Padova, 35128 Padova, ItalyDepartment of Medicine, Nephrology, Dialysis and Transplantation Unit, University of Padova, 35128 Padova, ItalyDepartment of Medicine, Nephrology, Dialysis and Transplantation Unit, University of Padova, 35128 Padova, ItalyRho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors of the RhoA small GTPase and found to belong to the AGC family of serine/threonine kinases. They were shown to be downstream effectors of RhoA and RhoC activation. They signal via phosphorylation of proteins such as MYPT-1, thereby regulating many key cellular functions including proliferation, motility and viability and the RhoA/ROCK signaling has been shown to be deeply involved in arterial hypertension, cardiovascular–renal remodeling, hypertensive nephropathy and posttransplant hypertension. Given the deep involvement of ROCK in cardiovascular–renal pathophysiology and the interaction of ROCK signaling with other signaling pathways, the reports of trials on the clinical beneficial effects of ROCK’s pharmacologic targeting are growing. In this current review, we provide a brief survey of the current understanding of ROCK-signaling pathways, also integrating with the more novel data that overall support a relevant role of ROCK for the cardiovascular–renal physiology and pathophysiology.https://www.mdpi.com/2077-0383/9/5/1328cardiovascular remodelingkidney remodelingROCKRhoRho kinasehypertension |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Teresa M. Seccia Matteo Rigato Verdiana Ravarotto Lorenzo A. Calò |
spellingShingle |
Teresa M. Seccia Matteo Rigato Verdiana Ravarotto Lorenzo A. Calò ROCK (RhoA/Rho Kinase) in Cardiovascular–Renal Pathophysiology: A Review of New Advancements Journal of Clinical Medicine cardiovascular remodeling kidney remodeling ROCK Rho Rho kinase hypertension |
author_facet |
Teresa M. Seccia Matteo Rigato Verdiana Ravarotto Lorenzo A. Calò |
author_sort |
Teresa M. Seccia |
title |
ROCK (RhoA/Rho Kinase) in Cardiovascular–Renal Pathophysiology: A Review of New Advancements |
title_short |
ROCK (RhoA/Rho Kinase) in Cardiovascular–Renal Pathophysiology: A Review of New Advancements |
title_full |
ROCK (RhoA/Rho Kinase) in Cardiovascular–Renal Pathophysiology: A Review of New Advancements |
title_fullStr |
ROCK (RhoA/Rho Kinase) in Cardiovascular–Renal Pathophysiology: A Review of New Advancements |
title_full_unstemmed |
ROCK (RhoA/Rho Kinase) in Cardiovascular–Renal Pathophysiology: A Review of New Advancements |
title_sort |
rock (rhoa/rho kinase) in cardiovascular–renal pathophysiology: a review of new advancements |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-05-01 |
description |
Rho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors of the RhoA small GTPase and found to belong to the AGC family of serine/threonine kinases. They were shown to be downstream effectors of RhoA and RhoC activation. They signal via phosphorylation of proteins such as MYPT-1, thereby regulating many key cellular functions including proliferation, motility and viability and the RhoA/ROCK signaling has been shown to be deeply involved in arterial hypertension, cardiovascular–renal remodeling, hypertensive nephropathy and posttransplant hypertension. Given the deep involvement of ROCK in cardiovascular–renal pathophysiology and the interaction of ROCK signaling with other signaling pathways, the reports of trials on the clinical beneficial effects of ROCK’s pharmacologic targeting are growing. In this current review, we provide a brief survey of the current understanding of ROCK-signaling pathways, also integrating with the more novel data that overall support a relevant role of ROCK for the cardiovascular–renal physiology and pathophysiology. |
topic |
cardiovascular remodeling kidney remodeling ROCK Rho Rho kinase hypertension |
url |
https://www.mdpi.com/2077-0383/9/5/1328 |
work_keys_str_mv |
AT teresamseccia rockrhoarhokinaseincardiovascularrenalpathophysiologyareviewofnewadvancements AT matteorigato rockrhoarhokinaseincardiovascularrenalpathophysiologyareviewofnewadvancements AT verdianaravarotto rockrhoarhokinaseincardiovascularrenalpathophysiologyareviewofnewadvancements AT lorenzoacalo rockrhoarhokinaseincardiovascularrenalpathophysiologyareviewofnewadvancements |
_version_ |
1724787480172953600 |