Spray drying OZ439 nanoparticles to form stable, water-dispersible powders for oral malaria therapy

Spray drying OZ439 nanoparticles to form stable, water-dispersible powders for oral malaria therapy

Abstract Background OZ439 is a new chemical entity which is active against drug-resistant malaria and shows potential as a single-dose cure. However, development of an oral formulation with desired exposure has proved problematic, as OZ439 is poorly soluble (BCS Class II drug). In order to be feasib...

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Bibliographic Details
Main Authors: Kurt D. Ristroph, Jie Feng, Simon A. McManus, Yingyue Zhang, Kai Gong, Hanu Ramachandruni, Claire E. White, Robert K. Prud’homme
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Translational Medicine
Subjects:
Nanocarrier
Hydrophobic ion pairing
Malaria
Spray drying
Drug delivery
Oral therapeutic
Online Access:http://link.springer.com/article/10.1186/s12967-019-1849-8

Internet

http://link.springer.com/article/10.1186/s12967-019-1849-8

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