Spray drying OZ439 nanoparticles to form stable, water-dispersible powders for oral malaria therapy
Abstract Background OZ439 is a new chemical entity which is active against drug-resistant malaria and shows potential as a single-dose cure. However, development of an oral formulation with desired exposure has proved problematic, as OZ439 is poorly soluble (BCS Class II drug). In order to be feasib...
Main Authors: | Kurt D. Ristroph, Jie Feng, Simon A. McManus, Yingyue Zhang, Kai Gong, Hanu Ramachandruni, Claire E. White, Robert K. Prud’homme |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-03-01
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Series: | Journal of Translational Medicine |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12967-019-1849-8 |
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