Enterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation.

Enterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation.

Upon infection of mammalian cells, enterohemorrhagic E. coli (EHEC) O157:H7 utilizes a type III secretion system to translocate the effectors Tir and EspF(U) (aka TccP) that trigger the formation of F-actin-rich 'pedestals' beneath bound bacteria. EspF(U) is localized to the plasma membran...

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Bibliographic Details
Main Authors: Didier Vingadassalom, Kenneth G Campellone, Michael J Brady, Brian Skehan, Scott E Battle, Douglas Robbins, Archana Kapoor, Gail Hecht, Scott B Snapper, John M Leong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2924363?pdf=render

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http://europepmc.org/articles/PMC2924363?pdf=render

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