The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake

The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake

Cytosolic lipid droplets (LDs) are storage organelles for neutral lipids derived from endogenous metabolism. Acyl-CoA synthetase family proteins are essential enzymes in this biosynthetic pathway, contributing activated fatty acids. Fluorescence microscopy showed that ACSL3 is localized to the endop...

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Bibliographic Details
Main Authors: Margarete Poppelreuther, Berenice Rudolph, Chen Du, Regina Großmann, Melanie Becker, Christoph Thiele, Robert Ehehalt, Joachim Füllekrug
Format: Article
Language:English
Published: Elsevier 2012-05-01
Series:Journal of Lipid Research
Subjects:
endoplasmic reticulum
lipid metabolism
fluorescence microscopy
membrane anchor
subcellular targeting
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520392191

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http://www.sciencedirect.com/science/article/pii/S0022227520392191

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