Trpm4 gene invalidation leads to cardiac hypertrophy and electrophysiological alterations.

Trpm4 gene invalidation leads to cardiac hypertrophy and electrophysiological alterations.

RATIONALE:TRPM4 is a non-selective Ca2+-activated cation channel expressed in the heart, particularly in the atria or conduction tissue. Mutations in the Trpm4 gene were recently associated with several human conduction disorders such as Brugada syndrome. TRPM4 channel has also been implicated at th...

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Bibliographic Details
Main Authors: Marie Demion, Jérôme Thireau, Mélanie Gueffier, Amanda Finan, Ziad Khoueiry, Cécile Cassan, Nicolas Serafini, Franck Aimond, Mathieu Granier, Jean-Luc Pasquié, Pierre Launay, Sylvain Richard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4274076?pdf=render

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http://europepmc.org/articles/PMC4274076?pdf=render

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