An effective vaginal gel to deliver CRISPR/Cas9 system encapsulated in poly (β-amino ester) nanoparticles for vaginal gene therapy

An effective vaginal gel to deliver CRISPR/Cas9 system encapsulated in poly (β-amino ester) nanoparticles for vaginal gene therapy

Background: Gene therapy has held promises for treating specific genetic diseases. However, the key to clinical application depends on effective gene delivery. Methods: Using a large animal model, we developed two pharmaceutical formulations for gene delivery in the pigs’ vagina, which were made up...

Full description

Bibliographic Details
Main Authors: Gang Niu, Zhuang Jin, Chong Zhang, Dan He, Xueqin Gao, Chenming Zou, Wei Zhang, Jiahui Ding, Bhudev C. Das, Konstantin Severinov, Inga Isabel Hitzeroth, Priya Ranjan Debata, Xin Ma, Xun Tian, Qinglei Gao, Jun Wu, Zeshan You, Rui Tian, Zifeng Cui, Weiwen Fan, Weiling Xie, Zhaoyue Huang, Chen Cao, Wei Xu, Hongxian Xie, Hongyan Xu, Xiongzhi Tang, Yan Wang, Zhiying Yu, Hui Han, Songwei Tan, Shuqin Chen, Zheng Hu
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:EBioMedicine
Subjects:
CRISPR/Cas9
Gene therapy
Local delivery
Poly (β-amino ester)
Vaginal gel
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420302723

Internet

http://www.sciencedirect.com/science/article/pii/S2352396420302723

Similar Items