FGF-2 promotes angiogenesis through a SRSF1/SRSF3/SRPK1-dependent axis that controls VEGFR1 splicing in endothelial cells

FGF-2 promotes angiogenesis through a SRSF1/SRSF3/SRPK1-dependent axis that controls VEGFR1 splicing in endothelial cells

Abstract Background Angiogenesis is the process by which new blood vessels arise from pre-existing ones. Fibroblast growth factor-2 (FGF-2), a leading member of the FGF family of heparin-binding growth factors, contributes to normal as well as pathological angiogenesis. Pre-mRNA alternative splicing...

Full description

Bibliographic Details
Main Authors: Tao Jia, Thibault Jacquet, Fabien Dalonneau, Pauline Coudert, Elisabeth Vaganay, Chloé Exbrayat-Héritier, Julien Vollaire, Véronique Josserand, Florence Ruggiero, Jean-Luc Coll, Béatrice Eymin
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Biology
Subjects:
Angiogenesis/endothelial cells/fibroblast growth factor/VEGFR1/SR proteins
Online Access:https://doi.org/10.1186/s12915-021-01103-3

Internet

https://doi.org/10.1186/s12915-021-01103-3

Similar Items