Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent

Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent

Mycobacteria remain an important problem worldwide, especially drug resistant human pathogens. Novel therapeutics are urgently needed to tackle both drug-resistant tuberculosis (TB) and difficult-to-treat infections with nontuberculous mycobacteria (NTM). Benzothiazole adamantyl amide had previously...

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Bibliographic Details
Main Authors: Mary A. De Groote, Thale C. Jarvis, Christina Wong, James Graham, Teresa Hoang, Casey L. Young, Wendy Ribble, Joshua Day, Wei Li, Mary Jackson, Mercedes Gonzalez-Juarrero, Xicheng Sun, Urs A. Ochsner
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Microbiology
Subjects:
NTM
tuberculosis
antibacterial therapeutics
benzothiazole amide
MmpL3
efficacy
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02231/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02231/full

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