Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs

Hasan and Berdichevsky report the use of 3D neuronal-astrocyte co-cultures in PDMS confinement to enable the study of aggregation, migration, contractility, and sorting of these cells. They show that aggregation is a neuron mediated process, and formation of astrocyte-rich sheaths in 3D cultures dep...

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Bibliographic Details
Main Authors: Md Fayad Hasan, Yevgeny Berdichevsky
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02104-2