Anti-Inflammatory Effect of Neoechinulin A from the Marine Fungus Eurotium sp. SF-5989 through the Suppression of NF-кB and p38 MAPK Pathways in Lipopolysaccharide-Stimulated RAW264.7 Macrophages

Anti-Inflammatory Effect of Neoechinulin A from the Marine Fungus Eurotium sp. SF-5989 through the Suppression of NF-кB and p38 MAPK Pathways in Lipopolysaccharide-Stimulated RAW264.7 Macrophages

In the course of a bioassay-guided study of metabolites from the marine fungus Eurotium sp. SF-5989, two diketopiperazine type indole alkaloids, neoechinulins A and B, were isolated. In this study, we investigated the anti-inflammatory effects of neoechinulins A (1) and B (2) on lipopolysaccharide (...

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Bibliographic Details
Main Authors: Kyoung-Su Kim, Xiang Cui, Dong-Sung Lee, Jae Hak Sohn, Joung Han Yim, Youn-Chul Kim, Hyuncheol Oh
Format: Article
Language:English
Published: MDPI AG 2013-10-01
Series:Molecules
Subjects:
neoechinulin A
Eurotium rubrum
RAW264.7 macrophages
inflammation
NF-κB
MAPK
Online Access:http://www.mdpi.com/1420-3049/18/11/13245

Internet

http://www.mdpi.com/1420-3049/18/11/13245

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