Mitochondrial Toxicity of Azithromycin Results in Aerobic Glycolysis and DNA Damage of Human Mammary Epithelia and Fibroblasts

Mitochondrial Toxicity of Azithromycin Results in Aerobic Glycolysis and DNA Damage of Human Mammary Epithelia and Fibroblasts

Mitochondria evolved from free-living bacteria via endocytosis within eukaryotic host cells millions of year ago. We hypothesized that antibiotics cause mammalian mitochondrial damage while causing bacterial lethality. Mitochondrial toxicity of azithromycin in human mammary epithelia MCF-12A and fib...

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Bibliographic Details
Main Authors: Xianpeng Jiang, Catherine Baucom, Robert L. Elliott
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Antibiotics
Subjects:
azithromycin
mitochondrial toxicity
aerobic glycolysis
DNA damage
Online Access:https://www.mdpi.com/2079-6382/8/3/110

Internet

https://www.mdpi.com/2079-6382/8/3/110

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