A novel role of ER stress signal transducer ATF6 in regulating enterovirus A71 viral protein stability

A novel role of ER stress signal transducer ATF6 in regulating enterovirus A71 viral protein stability

Abstract Background Due to limited coding capacity of viral genome, enterovirus A71 (EV-A71) co-opts host nuclear proteins for its replication. Upon ER stress, the ER-localized 90 kDa activating transcription factor 6 (p90ATF6) is proteolytically cleaved to produce the transcriptionally active amino...

Full description

Bibliographic Details
Main Authors: Jia-Rong Jheng, Kean-Seng Lau, Yueh-Wen Lan, Jim-Tong Horng
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Journal of Biomedical Science
Subjects:
ATF6
Enterovirus A71
Endoplasmic reticulum stress
Viral protein stability
Unfolded protein response
Viral replication
Online Access:http://link.springer.com/article/10.1186/s12929-018-0412-x

Internet

http://link.springer.com/article/10.1186/s12929-018-0412-x

Similar Items