TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT–GSK-3β–β-Catenin Signaling Pathway

TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT–GSK-3β–β-Catenin Signaling Pathway

PurposeThe tripartite motif-containing family member TRIM37 is involved in a number of important biological and pathological processes, and it has recently been shown to be an essential regulator of protein ubiquitination and a contributor to tumorigenesis. We previously showed that TRIM37 is overex...

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Bibliographic Details
Main Authors: Shiyu Chen, Zhiwei He, Changhao Zhu, Yanqing Liu, Lin Li, Lu Deng, Jun Wang, Chao Yu, Chengyi Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
TRIM37
pancreatic cancer
phosphatase and tensin homolog
stemness
chemoresistance
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.554787/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.554787/full

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