Platelet GPIIb supports initial pulmonary retention but inhibits subsequent proliferation of melanoma cells during hematogenic metastasis.

Platelet GPIIb supports initial pulmonary retention but inhibits subsequent proliferation of melanoma cells during hematogenic metastasis.

Platelets modulate the process of cancer metastasis. However, current knowledge on the direct interaction of platelets and tumor cells is mostly based on findings obtained in vitro. We addressed the role of the platelet fibrinogen receptor glycoprotein IIb (integrin αIIb) for experimental melanoma m...

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Bibliographic Details
Main Authors: Katrin Echtler, Ildiko Konrad, Michael Lorenz, Simon Schneider, Sebastian Hofmaier, Florian Plenagl, Konstantin Stark, Thomas Czermak, Anca Tirniceriu, Martin Eichhorn, Axel Walch, Georg Enders, Steffen Massberg, Christian Schulz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5333841?pdf=render

Internet

http://europepmc.org/articles/PMC5333841?pdf=render

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