Design, synthesis, and biological evaluation of novel bromo-pyrimidine analogues as tyrosine kinase inhibitors

In the present investigation we designed, synthesized and evaluated a novel series of bromo-pyrimidine analogues (6a-j, 7a-e, 9a-f, and 10a-f) as anticancer agents. The compounds were characterized using spectroscopic studies and elemental analysis and screened for their in vitro cytotoxic activity...

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Bibliographic Details
Main Authors: Chandrashekar S. Munikrishnappa, G.V. Suresh Kumar, Richie R. Bhandare, Afzal B. Shaik
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Arabian Journal of Chemistry
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535221000691