Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function

Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function

The interaction of mesenchymal stromal cells (MSCs) with natural killer (NK) cells is traditionally thought of as a static inhibitory model, whereby resting MSCs inhibit NK cell effector function. Here, we use a dynamic in vitro system of poly(I:C) stimulation to model the interaction of NK cells an...

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Bibliographic Details
Main Authors: Robert Michael Petri, Alexander Hackel, Katrin Hahnel, Claudia Alexandra Dumitru, Kirsten Bruderek, Stefanie B. Flohe, Annette Paschen, Stephan Lang, Sven Brandau
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Stem Cell Reports
Subjects:
mesenchymal stromal cell polarization
natural killer cell activation
Poly(I:C)
TGF-β
type I interferon
mucosal tissue
senescence
viral infection
TLR 3
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117302837

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http://www.sciencedirect.com/science/article/pii/S2213671117302837

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