Intronic tRNAs of mitochondrial origin regulate constitutive and alternative splicing

Intronic tRNAs of mitochondrial origin regulate constitutive and alternative splicing

Abstract Background The presence of nuclear mitochondrial DNA (numtDNA) has been reported within several nuclear genomes. Next to mitochondrial protein-coding genes, numtDNA sequences also encode for mitochondrial tRNA genes. However, the biological roles of numtDNA remain elusive. Results Employing...

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Bibliographic Details
Main Authors: Simon M. Hoser, Anne Hoffmann, Andreas Meindl, Maximilian Gamper, Jörg Fallmann, Stephan H. Bernhart, Lisa Müller, Melanie Ploner, Matthias Misslinger, Leopold Kremser, Herbert Lindner, Stephan Geley, Heiner Schaal, Peter F. Stadler, Alexander Huettenhofer
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Genome Biology
Subjects:
nimtRNA
tRNA-lookalikes
Intronic splicing enhancer (ISE)
Splicing regulatory element
numtDNA
tRNA
Online Access:https://doi.org/10.1186/s13059-020-02199-6

Internet

https://doi.org/10.1186/s13059-020-02199-6

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