Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet

Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet

AMP-activated protein kinase (AMPK) plays a key role in integrating metabolic pathways in response to energy demand. We identified a mutation in the γ1 subunit (γ1D316A) that leads to activation of AMPK. We generated mice with this mutation to study the effect of chronic liver-specific activation of...

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Bibliographic Details
Main Authors: Angela Woods, Jennet R. Williams, Phillip J. Muckett, Faith V. Mayer, Maria Liljevald, Mohammad Bohlooly-Y, David Carling
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
AMPK
fructose
lipogenesis
liver disease
NAFLD
steatosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717303285

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http://www.sciencedirect.com/science/article/pii/S2211124717303285

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